alpha-Synuclein Regulates Development and Function of Cholinergic Enteric Neurons in the Mouse Colon
M Swaminathan, C Fung, D Finkelstein, JC Bornstein, JPP Foong
Neuroscience | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2019
Alpha-Synuclein (α-Syn) is expressed in the central nervous system and the nervous system of the gut (enteric nervous system, ENS), and is well known to be the major constituent of Lewy bodies which are the hallmark of Parkinson's disease. Gastrointestinal disorders frequently manifest several years before motor deficits develop in Parkinson's patients. Despite extensive research on pathological rodent models, the physiological role of α-Syn in the normal ENS is unclear hampering analysis of its neuropathology. We compared the ENS in colons of α-Syn-knockout (α-Syn KO) and wild-type mice using immunohistochemistry and calcium-imaging of responses to synaptic input. We found that α-Syn is pre..View full abstract
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Awarded by National Health and Medical Research Council of Australia
Awarded by Australian Research Council
This research was supported by National Health and Medical Research Council of Australia Project grants #1099016 (JF and JB), and Australian Research Council grant #DP130101596 (JB).