Journal article

Autoimmunity plays a role in the onset of diabetes after 40 years of age

Olov Rolandsson, Christiane S Hampe, Stephen J Sharp, Eva Ardanaz, Heiner Boeing, Guy Fagherazzi, Francesca Romana Mancini, Peter M Nilsson, Kim Overvad, Maria-Dolores Chirlaque, Miren Dorronsoro, Marc J Gunter, Rudolf Kaaks, Timothy J Key, Kay-Tee Khaw, Vittorio Krogh, Tilman Kuehn, Domenico Palli, Salvatore Panico, Carlotta Sacerdote Show all

Diabetologia | SPRINGER | Published : 2019


AIMS/HYPOTHESIS: Type 1 and type 2 diabetes differ with respect to pathophysiological factors such as beta cell function, insulin resistance and phenotypic appearance, but there may be overlap between the two forms of diabetes. However, there are relatively few prospective studies that have characterised the relationship between autoimmunity and incident diabetes. We investigated associations of antibodies against the 65 kDa isoform of GAD (GAD65) with type 1 diabetes and type 2 diabetes genetic risk scores and incident diabetes in adults in European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct, a case-cohort study nested in the EPIC cohort. METHODS: GAD65 antibodies w..

View full abstract


Awarded by EU FP6 Programme

Awarded by National Institutes of Health

Awarded by Medical Research Council

Awarded by Murcia Regional Government

Awarded by NL Agency grant

Awarded by NIHR Cambridge Biomedical Research Centre

Funding Acknowledgements

Open access funding provided by Umea University. Funding for the InterAct project was provided by the EU FP6 Programme (grant number LSHM_CT_2006_037197). The autoantibody measurement was funded by Vasterbotten County Council and Umea University, Sweden (OR), the National Institutes of Health (DK26190) (CSH) and the Medical Research Council (MC_UU_ 12015/1) (NJW). OR: the Vasterbotten County Council, Umea University; MDC: Health Research Fund (FIS) of the Spanish Ministry of Health; Murcia Regional Government (N. 6236); EA: the Health Research Fund (FIS) of the Spanish Ministry of Health and Navarre Regional Government; RK: German Cancer Aid, the German Ministry of Research (BMBF); TJK: Cancer Research UK; KTK: the Medical Research Council UK, Cancer Research UK; PMN: the Swedish Research Council; KO: the Danish Cancer Society; SP: Compagnia di San Paolo; AMWS: the Dutch Ministry of Public Health, Welfare and Sports (VWS), the Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF); Statistics Netherlands; RT: AIRE-ONLUS Ragusa, AVIS-Ragusa, Sicilian Regional Government; AMWS: LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF); YTvdS: verification of diabetes cases was additionally funded by NL Agency grant IGE05012 and an Incentive Grant from the Board of the UMC Utrecht, LKResearch Funds, Dutch Prevention Funds; NGF: MRC core support (MC_ UU_12015/5); NIHR Cambridge Biomedical Research Centre (IS-BRC-1215-20014). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.