Journal article

The use of bioactive matrices in regenerative therapies for traumatic brain injury

Hui X Tan, Mark P Del Borgo, Marie-Isabel Aguilar, John S Forsythe, Juliet M Taylor, Peter J Crack

ACTA BIOMATERIALIA | ELSEVIER SCI LTD | Published : 2020

Abstract

Functional deficits due to neuronal loss are a common theme across multiple neuropathologies, including traumatic brain injury (TBI). Apart from mitigating cell death, another approach to treating brain injuries involves re-establishing the neural circuitry at the lesion site by utilizing exogeneous and/or endogenous stem cells to achieve functional recovery. While there has been limited success, the emergence of new bioactive matrices that promote neural repair introduces new perspectives on the development of regenerative therapies for TBI. This review briefly discusses current development on cell-based therapies and the use of bioactive matrices, hydrogels in particular, when incorporated..

View full abstract