Journal article

Bronchopulmonary dysplasia

Bernard Thebaud, Kara N Goss, Matthew Laughon, Jeffrey A Whitsett, Steven H Abman, Robin H Steinhorn, Judy L Aschner, Peter G Davis, Sharon A McGrath-Morrow, Roger F Soll, Alan H Jobe

Nature Reviews Disease Primers | NATURE PUBLISHING GROUP | Published : 2019


In the absence of effective interventions to prevent preterm births, improved survival of infants who are born at the biological limits of viability has relied on advances in perinatal care over the past 50 years. Except for extremely preterm infants with suboptimal perinatal care or major antenatal events that cause severe respiratory failure at birth, most extremely preterm infants now survive, but they often develop chronic lung dysfunction termed bronchopulmonary dysplasia (BPD; also known as chronic lung disease). Despite major efforts to minimize injurious but often life-saving postnatal interventions (such as oxygen, mechanical ventilation and corticosteroids), BPD remains the most fr..

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Awarded by National Heart, Lung and Blood Institute of the US National Institutes of Health (NIH)


Funding Acknowledgements

This work was supported by National Heart, Lung and Blood Institute of the US National Institutes of Health (NIH) grants (U01HL122642 and U01HL134745 to J.A.W.; RO1HL68702, R01HL145679 and U01HL12118-01 to S.H.A.; and K24 HL143283 to M.L.), and funding from the Australian National Health and Medical Research Council (NHMRC) to P.G.D. and from the Canadian Institute for Health Research, Stem Cell Network and the Ontario Institute for Regenerative Medicine to B.T. The authors thank J. Kitzmiller and C.-L. Na for their contributions in obtaining images.