Journal article

The effect of emerging nutraceutical interventions for clinical and biological outcomes in multiple sclerosis: A systematic review

Wolfgang Marx, Meghan Hockey, Amelia J McGuinness, Melissa Lane, John Christodoulou, Ingrid van der Mei, Michael Berk, Olivia M Dean, Bruce Taylor, Simon Broadley, Jeannette Lechner-Scott, Felice N Jacka, Robyn M Lucas, Anne-Louise Ponsonby



BACKGROUND: Due to the considerable burden of multiple sclerosis (MS)-related symptoms and the need to identify effective interventions to prevent disease progression, various nutraceutical interventions have been trialed as adjunctive treatments. The aim of this review was to investigate the efficacy and safety of nutraceutical interventions for clinical and biological outcomes in people with MS. METHODS: In accordance with PRISMA reporting guidelines, a systematic literature search was conducted using three electronic literature databases. Risk of bias was assessed using the Jadad scale. RESULTS: Thirty-seven randomized controlled trials, investigating fourteen nutraceuticals, were include..

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Awarded by NHMRC Senior Principal Research Fellowship

Awarded by NHMRC

Funding Acknowledgements

No direct funding was used to create this manuscript. WM is funded by a Deakin University postdoctoral fellowship. The research conducted at the Murdoch Children's Research Institute was supported by the Victorian Government's Operational Infrastructure Support Program. MB is supported by a NHMRC Senior Principal Research Fellowship (APP1059660 and APP1156072). MH is funded by Australian Rotary Health PhD Scholarship. OMD is a R.D. Wright Biomedical Research Fellow (APP 1145634) and has received grant support from the Brain and Behavior Foundation, Simons Autism Foundation, Stanley Medical Research Institute, Deakin University, Lilly, NHMRC and ASBDD/Servier. She has also received in kind support from BioMedica Nutracuticals, NutritionCare and Bioceuticals. ML is funded by a Deakin University PhD Scholarship. FJ has received Grant/Research support from the Brain and Behaviour Research Institute, the National Health and Medical Research Council (NHMRC), Australian Rotary Health, the Geelong Medical Research Foundation, the Ian Potter Foundation, Eli Lilly, Meat and Livestock Australia, The A2 Milk Company, BeFit Foods, Woolworths Limited, Fernwood Foundation, The Wilson Foundation, and The University of Melbourne and has received speakers honoraria from Sanofi-Synthelabo, Janssen Cilag, Servier, Pfizer, Health Ed, Network Nutrition, Angelini Farmaceutica, Eli Lilly and Metagenics. She is supported by an NHMRC Career Development Fellowship(2) (#1108125). Felice Jacka is currently writing two books for commercial publication and has a personal belief that good diet quality is important for mental and brain health. AJM is funded by an Australian Rotary Health/Ten Island Tassie Tag Along Tour Funding Partner PhD Scholarship. RL is funded by a NHMRC Senior Research Fellowship (#1107343)