Journal article

Subacute combined degeneration of the spinal cord masking motor neuron disease: a case report.

Paula Loveland, Aaron Wong, Vinojini Vivekanandam, Wen Kwang Lim

Journal of Medical Case Reports | Published : 2019

Abstract

BACKGROUND: Subacute combined degeneration of the spinal cord is a potentially reversible myelopathy typically associated with vitamin B12 deficiency. There is predominant involvement of spinal cord posterior and lateral tracts, and manifestations include peripheral paraesthesia, impaired proprioception, gait disturbance, neuropathy and cognitive changes. Motor neuron disease (MND) is an unremittingly progressive neurodegenerative disorder involving upper and lower motor neurons with an average prognosis of 2-3 years. The diagnosis is clinical and may be supported by electromyography. A subset of MND occurs concurrently with frontotemporal dementia (FTD-MND) and may be initially misdiagnosed..

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University of Melbourne Researchers