Wnt receptor gene FZD1 was associated with schizophrenia in genome-wide SNP analysis of the Australian Schizophrenia Research Bank cohort
Xiaoman Liu, Siew-Kee Low, Joshua R Atkins, Jing Qin Wu, William R Reay, Heath M Cairns, Melissa J Green, Ulrich Schall, Assen Jablensky, Bryan Mowry, Patricia T Michie, Stan V Catts, Frans Henskens, Christos Pantelis, Carmel Loughland, Alan V Boddy, Paul A Tooney, Rodney J Scott, Vaughan J Carr, Murray J Cairns
Australian & New Zealand Journal of Psychiatry | SAGE PUBLICATIONS LTD | Published : 2019
OBJECTIVES: Large-scale genetic analysis of common variation in schizophrenia has been a powerful approach to understanding this complex but highly heritable psychotic disorder. To further investigate loci, genes and pathways associated more specifically in the well-characterized Australian Schizophrenia Research Bank cohort, we applied genome-wide single-nucleotide polymorphism analysis in these three annotation categories. METHODS: We performed a case-control genome-wide association study in 429 schizophrenia samples and 255 controls. Post-genome-wide association study analyses were then integrated with genomic annotations to explore the enrichment of variation at the gene and pathway leve..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by NHMRC Senior Research Fellowship
Awarded by NHMRC Senior Principal Research Fellowship
The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: Data and samples were collected by the Australian Schizophrenia Research Bank (ASRB), supported by the Australian NHMRC, the Pratt Foundation, Ramsay Health Care and the Viertel Charitable Foundation. The ASRB was also supported by the Schizophrenia Research Institute (Australia), utilizing infrastructure funding from the NSW Health and the Macquarie Group Foundation. DNA analysis was supported by the Neurobehavioral Genetics Unit, utilizing funding from NSW Health. J.R.A. was supported by the University of Newcastle RHD and an Emlyn and Jennie Thomas Postgraduate Medical Research Scholarship. W.R.R. is supported by an Australian Postgraduate Award. C.L. was supported by National Health and Medical Research Council (NHMRC) Project Grants (1067137). M.J.C. was supported by an NHMRC Senior Research Fellowship (1121474). C.P. was supported by a NHMRC Senior Principal Research Fellowship (628386 & 1105825).