Journal article
Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways
B Huang, Z Chen, L Geng, J Wang, H Liang, Y Cao, H Chen, W Huang, M Su, H Wang, Y Xu, Y Liu, B Lu, H Xian, H Li, H Li, L Ren, J Xie, L Ye, H Wang Show all
Cell | CELL PRESS | Published : 2019
Abstract
Single-cell and risk gene analysis of children with undifferentiated colitis, Crohn's disease, and ulcerative colitis identifies common underlying mechanisms of pathogenesis and reveals the potential therapeutic benefit of modulating cAMP signaling via the drug dipyridamole.
Grants
Awarded by Pennsylvania Department of Education
Funding Acknowledgements
The National Natural Science Foundation of China (91742109, 31770978, 31722003, 31770925, 31370847, and 81770552), the National Key Research and Development Program (2016YFC0900102), the National Science and Technology Major Project (2018ZX10302205), the Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease (2019B030301004), the China Postdoctoral Science Foundation (2017M622656), the Guangzhou Women and Children's Medical Center Fund (5001-3001032, Pre-NSFC-2016-004, and 5001-3001068) and the National Health and Medical Research Council of Australia (1037321, 1105209, 1143976, and 1080321, to A.L.) funded this study. We thank patients and their guardians, the Clinical Biological Resource Bank, and the National Supercomputer Center in Guangzhou at Sun Yat-Sen University for support of the study.