Diet-Induced Modification of the Sperm Epigenome Programs Metabolism and Behavior
Carina Bodden, Anthony J Hannan, Amy C Reichelt
TRENDS IN ENDOCRINOLOGY AND METABOLISM | ELSEVIER SCIENCE LONDON | Published : 2020
Globally, obesity has reached epidemic proportions. The rapidly increasing numbers of overweight people can be traced back to overconsumption of energy-dense, poor-quality foods as well as physical inactivity. This development has far-reaching and costly implications. Not only is obesity associated with serious physiological and psychological complications, but mounting evidence also indicates a ripple effect through generations via epigenetic changes. Parental obesity could induce intergenerational and transgenerational changes in metabolic and brain function of the offspring. Most research has focused on maternal epigenetic and gestational effects; however, paternal contributions are likel..View full abstract
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Awarded by Australian Research Council (ARC)
A.C.R. receives funding from a Canada First Research Excellent Fund BrainsCAN Senior Fellowship. A.J. H. is a National Health and Medical Research Council (NHMRC) Principal Research Fellow and is also supported by NHMRC Project Grants and the DHB Foundation Equity Trustees. This work was funded by an Australian Research Council (ARC) Discovery Project grant (DP180101974 to A.C.R. and A. J.H.). The Florey Institute ofNeuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.