Computed Tomography-Based Body Composition Is Not Consistently Associated with Outcome in Older Patients with Colorectal Cancer
Stephanie MLM Looijaard, Carel GM Meskers, Monique S Slee-Valentijn, Donald E Bouman, AN Machteld Wymenga, Joost M Klaase, Andrea B Maier
The Oncologist | WILEY | Published : 2019
BACKGROUND: Current literature is inconsistent in the associations between computed tomography (CT)-based body composition measures and adverse outcomes in older patients with colorectal cancer (CRC). Moreover, the associations with consecutive treatment modalities have not been studied. This study compared the associations of CT-based body composition measures with surgery- and chemotherapy-related complications and survival in older patients with CRC. MATERIALS AND METHODS: A retrospective single-center cohort study was conducted in patients with CRC aged ≥65 years who underwent elective surgery between 2010 and 2014. Gender-specific standardized scores of preoperative CT-based skeletal mu..View full abstract
Awarded by European Union's Horizon 2020 research and innovation program under the Marie-Sklodowska-Curie grant
We thank Willem G.P.M. Looijaard for being the second assessor in case of doubt about inclusion or multiplication of surface area in included CT scans. Moreover, we thank Anna F. Voskuilen (A.V.) for analyzing a selection of CT scans to determine the interobserver correlation coefficient. This work was supported by the European Union's Horizon 2020 research and innovation program under the Marie-Sklodowska-Curie grant agreement 675003 (PANINI program) and by an unrestricted grant of the University of Melbourne, Australia, received by Professor Andrea B. Maier. The funders had no role in the design and conduct of the study, data collection and analysis, interpretation of data, or preparation of the manuscript. This study has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. The study was approved by the Medical Ethics Committee of the Amsterdam University Medical Center, location VU Medical Center, Amsterdam, The Netherlands (number of approval 2015.166) with site-specific approval of Medical Spectrum Twente, Enschede, The Netherlands. Written informed consent was waived because of the retrospective design of the study.