Journal article

Detailed phenotyping of posterior vs. anterior circulation ischemic stroke: a multi-center MRI study

Petrea Frid, Mattias Drake, AK Giese, J Wasselius, MD Schirmer, KL Donahue, L Cloonan, R Irie, MJRJ Bouts, EC McIntosh, SJT Mocking, AV Dalca, R Sridharan, H Xu, E Giralt-Steinhauer, L Holmegaard, K Jood, J Roquer, JW Cole, PF McArdle Show all

JOURNAL OF NEUROLOGY | SPRINGER HEIDELBERG | Published : 2019

Abstract

OBJECTIVE: Posterior circulation ischemic stroke (PCiS) constitutes 20-30% of ischemic stroke cases. Detailed information about differences between PCiS and anterior circulation ischemic stroke (ACiS) remains scarce. Such information might guide clinical decision making and prevention strategies. We studied risk factors and ischemic stroke subtypes in PCiS vs. ACiS and lesion location on magnetic resonance imaging (MRI) in PCiS. METHODS: Out of 3,301 MRIs from 12 sites in the National Institute of Neurological Disorders and Stroke (NINDS) Stroke Genetics Network (SiGN), we included 2,381 cases with acute DWI lesions. The definition of ACiS or PCiS was based on lesion location. We compared th..

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Grants

Awarded by Spain's Ministry of Health (Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III FEDER)


Awarded by Swedish Research Council


Awarded by Swedish Heart and Lung Foundation


Awarded by Swedish government


Awarded by ALF-agreement


Awarded by National Institute of Neurological Disorders and Stroke (NINDS)


Awarded by VA RRD


Awarded by NINDS


Awarded by SiGN grant


Awarded by US NIH-NINDS


Awarded by NIH NIBIB NAC


Awarded by NIH-NINDS


Funding Acknowledgements

Dr. Roquer: supported in part by Spain's Ministry of Health (Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III FEDER, RD12/0042/0020). Dr. Jern: The Swedish Research Council (2018-02543), The Swedish Heart and Lung Foundation (20160316) as well as grants from the Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement (ALFGBG-720081). Dr. Meschia: receives funding for the CREST-2 Trial from the NINDS U01 NS080168 and from Mayo Clinic through the Earl and Nyda Swanson Neurosciences Research Fund and the Harley N. and Rebecca N. Hotchkiss Endowed Fund in Neuroscience Research, Honoring Ken and Marietta. Dr. Kittner: supported in part by award number U01NS069208 from the National Institute of Neurological Disorders and Stroke (NINDS). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NINDS or the National Institutes of Health. Dr. Kittner's effort on this project was partly supported by VA RR&D N1699-R and NINDS R01NS100178 and R01NS105150. Dr. Mitchell: supported in part by SiGN grant for funding R01NS100178. Dr. Rosand: supported in part by US NIH-NINDS R01NS100178 and R01NS086905. Dr. Golland: NIH NIBIB NAC P41EB015902. Dr. Rost: NIH-NINDS R01 NS086905 (MRI-GENIE study/Rost PI). Dr. Lindgren: the Lund Stroke Register has been supported by the Swedish Heart and Lung Foundation, Skane University Hospital, Region Skane, the Freemasons Lodge of Instruction EOS in Lund, Foundation of Fars and Frosta (one of Sparbanken Skane's ownership Foundations), and Lund University.