Point-of-care testing and treatment of sexually transmitted infections to improve birth outcomes in high-burden, low-income settings: Study protocol for a cluster randomized crossover trial (the WANTAIM Trial, Papua New Guinea).
Andrew J Vallely, William S Pomat, Caroline Homer, Rebecca Guy, Stanley Luchters, Glen DL Mola, Grace Kariwiga, Lisa M Vallely, Virginia Wiseman, Chris Morgan, Handan Wand, Stephen J Rogerson, Sepehr N Tabrizi, David M Whiley, Nicola Low, Rosanna Peeling, Peter Siba, Michaela Riddell, Moses Laman, John Bolnga Show all
Wellcome Open Research | F1000 Research Ltd | Published : 2019
Background:Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis and bacterial vaginosis have been associated with preterm birth and low birth weight, and are highly prevalent among pregnant women in many low- and middle-income settings. There is conflicting evidence on the potential benefits of screening and treating these infections in pregnancy. Newly available diagnostic technologies make it possible, for the first time, to conduct definitive field trials to fill this knowledge gap. The primary aim of this study is to evaluate whether antenatal point-of-care testing and immediate treatment of these curable sexually transmitted and genital infections (STIs) leads to reductio..View full abstract