Gender differences in mortality and quality of life after septic shock: A post-hoc analysis of the ARISE study

Nora Luethi; Michael Bailey; Alisa Higgins; Belinda Howe; Sandra Peake; Anthony Delaney; Rinaldo Bellomo; V Bennett; J Board; P McCracken; S McGloughlin; V Nanjayya; A Teo; E Hill; P Jones E O'Brien; F Sawtell; K Schimanski; D Wilson; R Bellomo; S Bolch; G Eastwood; F Kerr; L Peak; H Young; J Edington; J Fletcher; J Smith; D Ghelani; K Nand; T Sara; A Cross; D Flemming; M Grummisch; A Purdue; E Fulton; K Grove; A Harney; K Milburn; R Millar; I Mitchell; H Rodgers; S Scanlon; T Coles; H Connor; J Dennett; A Van Berkel; S Barrington-Onslow; S Henderson; J Mehrtens; J Dryburgh; A Tankel; G Braitberg; B O'Bree; K Shepherd; S Vij; S Allsop; D Haji; K Haji; J Vuat; A Bone; T Elderkin; N Orford; M Ragg; S Kelly; D Stewart; N Woodward; V-P Harjola; M Okkonen Pettila; S Sutinen; E Wilkman; J Fratzia; J Halkhoree; S Treloar; K Ryan; T Sandford; J Walsham; C Jenkins; D Williamson; J Burrows; D Hawkins; C Tang; A Dimakis; A Holdgate; S Micallef; M Parr; H White; L Morrison; K Sosnowski; R Ramadoss; N Soar; J Wood; M Franks; A Williams; C Hogan; R Song; A Tilsley; D Rainsford; R Wells; J Dowling; P Galt; T Lamac; D Lightfoot; C Walker; K Braid; T DeVillecourt; HS Tan; I Seppelt; LF Chang; WS Cheung; SK Fok; PK Lam; SM Lam; HM So; W Yan; A Altea; B Lancashire; CD Gomersall; CA Graham; P Leung; S Arora; F Bass; Y Shehabi; J Isoardi; K Isoardi; D Powrie; S Lawrence; A Ankor; L Chester; M Davies; S O'Connor; A Poole; T Soulsby; K Sundararajan; J Williams; JH Greenslade; C MacIsaac; K Gorman; A Jordan; L Moore; S Ankers; S Bird; A Delaney; T Fogg; E Hickson; T Jewell; K Kyneur; A O'Connor; J Townsend; E Yarad; S Brown; J Chamberlain; J Cooper; E Jenkinson; E McDonald; S Webb; H Buhr; J Coakley; J Cowell; D Hutch; D Gattas; M Keir; D Rajbhandari; C Rees; S Baker; B Roberts; E Farone; J Holmes; J Santamaria; C Winter; A Finckh; S Knowles; J McCabe; P Nair; C Reynolds; B Ahmed; D Barton; E Meaney; A Nichol; R Harris; L Shields; K Thomas; S Karlsson; A Kuitunen; A Kukkurainen; J Tenhunen; S Varila; N Ryan; C Trethewy; J Crosdale; JC Smith; M Vellaichamy; J Furyk; G Gordon; L Jones; S Senthuran; S Bates; J Butler; C French; A Tippett; J Kelly; J Kwans; M Murphy; D O'Flynn; C Kurenda; T Otto; S Peake; V Raniga; P Williams; HF Ho; A Leung; H Wu

Journal article

Gender differences in mortality and quality of life after septic shock: A post-hoc analysis of the ARISE study

Nora Luethi, Michael Bailey, Alisa Higgins, Belinda Howe, Sandra Peake, Anthony Delaney, Rinaldo Bellomo, V Bennett, J Board, P McCracken, S McGloughlin, V Nanjayya, A Teo, E Hill, P Jones E O'Brien, F Sawtell, K Schimanski, D Wilson, R Bellomo, S Bolch Show all

Journal of Critical Care | W B SAUNDERS CO-ELSEVIER INC | Published : 2020

DOI: 10.1016/j.jcrc.2019.11.002

Abstract

PURPOSE: To assess the impact of gender and pre-menopausal state on short- and long-term outcomes in patients with septic shock. MATERIAL AND METHODS: Cohort study of the Australasian Resuscitation in Sepsis Evaluation (ARISE) trial, an international randomized controlled trial comparing early goal-directed therapy (EGDT) to usual care in patients with early septic shock, conducted between October 2008 and April 2014. The primary exposure in this analysis was legal gender and the secondary exposure was pre-menopausal state defined by chronological age (≤ 50 years). RESULTS: 641 (40.3%) of all 1591 ARISE trial participants in the intention-to-treat population were females and overall, 337 (21..

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University of Melbourne Researchers

Michael Bailey Author Medicine - Austin Health

Rinaldo Bellomo Author Critical Care

George Braitberg Author Critical Care

Grants

Awarded by National Health and Medical Research Council

Awarded by NHMRC

Funding Acknowledgements

The ARISE trial was funded by the National Health and Medical Research Council (No. 491075 and 1021165) and coordinated by the Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne. Ms. Higgins was supported by an NHMRC post-graduate scholarship (No. 579709). The remaining authors have disclosed that they do not have any conflicts of interest.