Journal article

Serum Calcification Propensity and Clinical Events in CKD

Joshua D Bundy, Xuan Cai, Rupal C Mehta, Julia J Scialla, Ian H de Boer, Chi-yuan Hsu, Alan S Go, Mirela A Dobre, Jing Chen, Panduranga S Rao, Mary B Leonard, James P Lash, Geoffrey A Block, Raymond R Townsend, Harold Feldman, Edward R Smith, Andreas Pasch, Tamara Isakova, Lawrence J Appel, undefined Feldman Show all

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | AMER SOC NEPHROLOGY | Published : 2019

Abstract

BACKGROUND AND OBJECTIVES: Patients with CKD are at high risk for cardiovascular disease, ESKD, and mortality. Vascular calcification is one pathway through which cardiovascular disease risks are increased. We hypothesized that a novel measure of serum calcification propensity is associated with cardiovascular disease events, ESKD, and all-cause mortality among patients with CKD stages 2-4. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Among 3404 participants from the prospective, longitudinal Chronic Renal Insufficiency Cohort Study, we quantified calcification propensity as the transformation time (T50) from primary to secondary calciprotein particles, with lower T50 corresponding to high..

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Grants

Awarded by National Institute of Diabetes and Digestive and Kidney Disorders (NIDDK)


Awarded by NHLBI Cardiovascular Epidemiology training grant


Awarded by NIDDK


Awarded by NHLBI


Awarded by Perelman School of Medicine at the University of Pennsylvania Clinical and Translational Science Award National Institutes of Health/National Center for Advancing Translational Sciences


Awarded by Johns Hopkins Institute for Clinical and Translational Research


Awarded by University of Maryland General Clinical Research Center


Awarded by Clinical and Translational Science Collaborative of Cleveland


Awarded by Michigan Institute for Clinical and Health Research


Awarded by University of Illinois at Chicago Clinical and Translational Science Awards


Awarded by Tulane Center of Biomedical Research Excellence for Clinical and Translational Research in Cardiometabolic Diseases


Awarded by Kaiser Permanente National Institutes of Health/National Center for Research Resources University of California San Francisco Clinical and Translational Science Institute


Awarded by NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES


Funding Acknowledgements

This work was supported by the National Institute of Diabetes and Digestive and Kidney Disorders (NIDDK; grant P30DK114857). Dr. Bundy is supported by the NHLBI Cardiovascular Epidemiology training grant T32HL069771. Dr. de Boer is supported by a grant from NIDDK(R01DK099199). Dr. Dobre is supported by a grant from NHLBI (R01HL141846). Dr. Isakova is supported by grants from NIDDK (R01DK102438, R01DK110087, and U01DK099930). Dr. Scialla is supported by a grant from NIDDK(R01DK111952). Funding for the Chronic Renal Insufficiency Cohort study was obtained under a cooperative agreement from NIDDK (U01DK060990, U01DK060984, U01DK061022, U01DK061021, U01DK061028, U01DK060980, U01DK060963, and U01DK060902). In addition, this study was supported in part by the Perelman School of Medicine at the University of Pennsylvania Clinical and Translational Science Award National Institutes of Health/National Center for Advancing Translational Sciences (UL1TR000003), the Johns Hopkins Institute for Clinical and Translational Research (UL1TR000424), University of Maryland General Clinical Research Center (M01RR-16500), Clinical and Translational Science Collaborative of Cleveland (UL1TR000439), Michigan Institute for Clinical and Health Research (UL1TR000433), University of Illinois at Chicago Clinical and Translational Science Awards (UL1RR029879), Tulane Center of Biomedical Research Excellence for Clinical and Translational Research in Cardiometabolic Diseases (P20 GM109036), and Kaiser Permanente National Institutes of Health/National Center for Research Resources University of California San Francisco Clinical and Translational Science Institute (UL1RR024131).