Effect of Salt Supplementation on Sympathetic Activity and Endothelial Function in Salt-Sensitive Type 2 Diabetes
Sara Baqar, Yee Wen Kong, Angela X Chen, Christopher O'Callaghan, Richard J MacIsaac, Maree Bouterakos, Gavin W Lambert, George Jerums, Elisabeth E Lambert, Elif Ekinci
The Journal of Clinical Endocrinology & Metabolism | ENDOCRINE SOC | Published : 2020
CONTEXT: Lower sodium intake is paradoxically associated with higher mortality in type 2 diabetes (T2D). OBJECTIVE: To determine whether sympathetic nervous system (SNS) activation and endothelial dysfunction contribute to these observations, we examined the effect of salt supplementation on these systems in people with T2D with habitual low sodium. We hypothesized that salt supplementation would lower SNS activity and improve endothelial function compared to placebo. DESIGN: We conducted a randomized, double-blinded, placebo-controlled crossover trial. SETTING: The study took place in a tertiary referral diabetes outpatient clinic. PARTICIPANTS: Twenty-two people with T2D with habitual low ..View full abstract
Awarded by National Health and Medical Research Council (NHMRC) Early Career Research Fellowship
Awarded by National Heart Foundation Health Professional Scholarship
Awarded by NHMRC Senior Research Fellowship
This work was supported by an National Health and Medical Research Council (NHMRC) Early Career Research Fellowship (No. 1054312 to E.I.E.), a Viertel Clinical Investigatorship, a Sir Edward Weary Dunlop Medical Research Foundation grant, an RACP fellowship, a National Heart Foundation Health Professional Scholarship (No. 100287 to S.B.), and an NHMRC Senior Research Fellowship (No. 1042492 to G.W.L.).