Journal article

Persistent deleterious effects of an unstable deleteriousWolbachiainfection

Perran Ross, Jason Axford, Ashley Callahan, Kelly Richardson, Ary Hoffmann

Cold Spring Harbor Laboratory | Published : 2019

Abstract

Wolbachia are being used to reduce dengue transmission by Aedes aegypti mosquitoes around the world. To date releases have mostly involved Wolbachia strains with limited fitness effects but strains with larger fitness costs could be used to suppress mosquito populations. However, such infections are expected to evolve towards decreased deleterious effects. Here we investigate potential evolutionary changes in the w MelPop infection transferred from Drosophila melanogaster to Aedes aegypti more than ten years (~120 generations) ago. We show that most deleterious effects of this infection have persisted despite strong selection to ameliorate them. The w MelPop infection is difficult to maintai..

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