Evolution and global transmission of a multidrug-resistant, community-associated methicillin-resistant staphylococcus aureus lineage from the Indian subcontinent

EJ Steinig; S Duchene; DA Robinson; S Monecke; M Yokoyama; M Laabei; P Slickers; P Andersson; D Williamson; A Kearns; RV Goering; E Dickson; R Ehricht; M Ip; MVN O’sullivan; GW Coombs; A Petersen; G Brennan; AC Shore; DC Coleman; A Pantosti; HD Lencastre; H Westh; N Kobayashi; H Heffernan; B Strommenger; F Layer; S Weber; HV Aamot; L Skakni; SJ Peacock; D Sarovich; S Harris; J Parkhill; RC Massey; MTG Holden; SD Bentley; SYC Tong

Journal article

Evolution and global transmission of a multidrug-resistant, community-associated methicillin-resistant staphylococcus aureus lineage from the Indian subcontinent

EJ Steinig, S Duchene, DA Robinson, S Monecke, M Yokoyama, M Laabei, P Slickers, P Andersson, D Williamson, A Kearns, RV Goering, E Dickson, R Ehricht, M Ip, MVN O’sullivan, GW Coombs, A Petersen, G Brennan, AC Shore, DC Coleman Show all

Mbio | AMER SOC MICROBIOLOGY | Published : 2019

DOI: 10.1128/mBio.01105-19

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Abstract

The evolution and global transmission of antimicrobial resistance have been well documented for Gram-negative bacteria and health care-associated epidemic pathogens, often emerging from regions with heavy antimicrobial use. However, the degree to which similar processes occur with Gram-positive bacteria in the community setting is less well understood. In this study, we traced the recent origins and global spread of a multidrug-resistant, community-associated Staphylococcus aureus lineage from the Indian subcontinent, the Bengal Bay clone (ST772). We generated whole-genome sequence data of 340 isolates from 14 countries, including the first isolates from Bangladesh and India, to reconstruct ..

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University of Melbourne Researchers

Eike Steinig Author

Sebastian Duchene Garzon Author

Patiyan Andersson Author

Deborah Williamson Author

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council (number 1145033 to Steven Y. C. Tong and number 1065908 to Matthew V. N. O'Sullivan), by a National Institutes of Health grant (GM080602 to D. Ashley Robinson), and by the Irish Health Research Board (HRA-POR-2015-1051 to David C. Coleman and Anna C. Shore).