Journal article

Characterising the brain metalloproteome in Down syndrome patients with concomitant Alzheimer's pathology

Nakisa Malakooti, Blaine Roberts, Melanie A Pritchard, Irene Volitakis, Ron C Kim, Ira T Lott, Catriona A McLean, David Finkelstein, Paul A Adlard

Metallomics | OXFORD UNIV PRESS | Published : 2020

Abstract

Down syndrome (DS) is a common intellectual disability, with an incidence of 1 in 700 and is caused by trisomy 21. People with DS develop Alzheimer's disease (AD)-like neuropathology by the age of 40. As metal ion dyshomeostasis (particularly zinc, iron and copper) is one of the characteristics of AD and is believed to be involved in the pathogenesis of disease, we reasoned that it may also be altered in DS. Thus, we used inductively coupled plasma mass spectrometry to examine metal levels in post-mortem brain tissue from DS individuals with concomitant AD pathology. Size exclusion-ICPMS was also utilised to characterise the metalloproteome in these cases. We report here for the first time t..

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Grants

Awarded by NHMRC Dementia Leadership Fellowship


Awarded by NHMRC


Funding Acknowledgements

Nakisa Malakooti was supported by a NHMRC Dora Lush scholarship and Blaine Roberts by a NHMRC Dementia Leadership Fellowship (APP1138673) and NHMRC project grant (APP1164692). The Florey Institute of Neuroscience and Mental Health acknowledge the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.