Journal article
Differential left ventricular and left atrial remodelling in heart failure with preserved ejection fraction patients with and without diabetes
GS Gulsin, P Kanagala, DCS Chan, ASH Cheng, L Athithan, MPM Graham-Brown, A Singh, J Yang, Z Li, K Khunti, MJ Davies, JR Arnold, IB Squire, LL Ng, GP McCann
Therapeutic Advances in Endocrinology and Metabolism | SAGE PUBLICATIONS LTD | Published : 2019
Abstract
Background: Attempts to characterize cardiac structure in heart failure with preserved ejection fraction (HFpEF) in people with type 2 diabetes (T2D) have yielded inconsistent findings. We aimed to determine whether patients with HFpEF and T2D have a distinct pattern of cardiac remodelling compared with those without diabetes and whether remodelling was related to circulating markers of inflammation and fibrosis and clinical outcomes. Methods: We recruited 140 patients with HFpEF (75 with T2D and 65 without). Participants underwent comprehensive cardiovascular phenotyping, including echocardiography, cardiac magnetic resonance imaging and plasma biomarker profiling. Results: Patients with T2..
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Awarded by National Space Biomedical Research Institute
Funding Acknowledgements
The author(s) disclose receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by and falls under the portfolio of research conducted within the National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit. Overall project grant: IRS IS_BRU_0211_20033.