Differential left ventricular and left atrial remodelling in heart failure with preserved ejection fraction patients with and without diabetes.
Gaurav S Gulsin, Prathap Kanagala, Daniel CS Chan, Adrian SH Cheng, Lavanya Athithan, Matthew PM Graham-Brown, Anvesha Singh, Jing Yang, Zhuyin Li, Kamlesh Khunti, Melanie J Davies, Jayanth R Arnold, Iain B Squire, Leong L Ng, Gerry P McCann
Therapeutic Advances in Endocrinology and Metabolism | Published : 2019
Background: Attempts to characterize cardiac structure in heart failure with preserved ejection fraction (HFpEF) in people with type 2 diabetes (T2D) have yielded inconsistent findings. We aimed to determine whether patients with HFpEF and T2D have a distinct pattern of cardiac remodelling compared with those without diabetes and whether remodelling was related to circulating markers of inflammation and fibrosis and clinical outcomes. Methods: We recruited 140 patients with HFpEF (75 with T2D and 65 without). Participants underwent comprehensive cardiovascular phenotyping, including echocardiography, cardiac magnetic resonance imaging and plasma biomarker profiling. Results: Patients with T2..View full abstract