Aspergillus Infections and Progression of Structural Lung Disease in Children with Cystic Fibrosis
Oded Breuer, Andre Schultz, Luke W Garratt, Lidija Turkovic, Tim Rosenow, Conor P Murray, Yuliya Karpievitch, Lauren Akesson, Samuel Dalton, Peter D Sly, Sarath Ranganathan, Stephen M Stick, Daan Caudri
American Journal of Respiratory and Critical Care Medicine | AMER THORACIC SOC | Published : 2020
Rationale: Recent data show that Aspergillus species are prevalent respiratory infections in children with cystic fibrosis (CF). The biological significance of these infections is unknown.Objectives: We aimed to evaluate longitudinal associations between Aspergillus infections and lung disease in young children with CF.Methods: Longitudinal data on 330 children participating in the Australian Respiratory Early Surveillance Team for Cystic Fibrosis surveillance program between 2000 and 2018 who underwent annual chest computed tomography (CT) imaging and BAL were used to determine the association between Aspergillus infections and the progression of structural lung disease. Results were adjust..View full abstract
Awarded by National Health and Medical Research Council
AREST CF is supported by Cystic Fibrosis Foundation Therapeutics, Inc., USA and Cystic Fibrosis Australia, and National Health and Medical Research Council grants APP1000896 and 1020555. O.B. has been supported by a Lowy Foundation Pediatric Fellowship arranged by AUSiMED (Australia/Israel Medical Research). D.C. received support for a Research Fellowship from the Rothwell Foundation, the Ter Meulen Grant of the Royal Netherlands Academy of Arts and Sciences, and the Sophia Childrens' Hospital Fund. None of the funding bodies were in any way involved in the data collection, interpretation of the data, or writing of the manuscript.