Journal article

Dose Articulation in Preclinical and Clinical Stroke Recovery: Refining a Discovery Research Pipeline and Presenting a Scoping Review Protocol

Emily Dalton, Leonid Churilov, Natasha A Lennin, Dale Corbett, Kathryn S Hayward

Frontiers in Neurology | FRONTIERS MEDIA SA | Published : 2019

Abstract

Introduction: Despite an increase in the quality of clinical trials in stroke recovery, interventions have failed to markedly impact the trajectory of recovery after stroke. Failure may be due to the lack of consideration for the complexity of dose and its articulation within research trials. Prior to commencing the scoping review, we identified two research gaps to be addressed. Firstly, transparent application of a multidimensional definition of dose to clinical trial phases and secondly, the development of a quality tool to critique the articulation of dose across the pipeline. Building on this, we present the protocol for a scoping review that aims to synthesis what is known about dose a..

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Grants

Awarded by National Health and Medical Research Council


Awarded by National Heart Foundation of Australia


Funding Acknowledgements

ED was supported by an Australian Government Research Training Program Scholarship through the University of Melbourne. KH was supported by National Health and Medical Research Council Early Career Research Fellowship (APP1088449). NL was supported by the National Heart Foundation of Australia (GNT102055).