Journal article

Nanomechanical mapping reveals localized stiffening of the basilar membrane after cochlear implantation

Jessica K Choong, Amy J Hampson, Kate M Brody, Jonathon Lo, Christofer W Bester, Anthony W Gummer, Nicholas P Reynolds, Stephen J O'Leary

HEARING RESEARCH | ELSEVIER | Published : 2020

Abstract

Cochlear implantation leads to many structural changes within the cochlea which can impair residual hearing. In patients with preserved low-frequency hearing, a delayed hearing loss can occur weeks-to-years post-implantation. We explore whether stiffening of the basilar membrane (BM) may be a contributory factor in an animal model. Our objective is to map changes in morphology and Young's modulus of basal and apical areas of the BM after cochlear implantation, using quantitative nanomechanical atomic force microscopy (QNM-AFM) after cochlear implant surgery. Cochlear implantation was undertaken in the guinea pig, and the BM was harvested at four time-points: 1 day, 14 days, 28 days and 84 da..

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Grants

Awarded by National Health and Medical Research Council (Australia)


Awarded by Australian Research Council


Funding Acknowledgements

SJO is funded by the National Health and Medical Research Council (Australia) GNT1125790 and GNT1078673. NPR would like to thank the Australian Research Council (IC140100023) and Swinburne University of Technology for funding. JC was a recipient of the Hugh Noel Puckle Scholarship from the University of Melbourne. This research was funded by the Garnett Passe and Rodney Williams Memorial Foundation and a generous bequest from the family of the late Gordon Darling, AC.