Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

Tuo Yang; Lee M Yeoh; Madel V Tutor; Matthew W Dixon; Paul J McMillan; Stanley C Xie; Jessica L Bridgford; David L Gillett; Michael F Duffy; Stuart A Ralph; Malcolm J McConville; Leann Tilley; Simon A Cobbold

Journal article

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

Tuo Yang, Lee M Yeoh, Madel V Tutor, Matthew W Dixon, Paul J McMillan, Stanley C Xie, Jessica L Bridgford, David L Gillett, Michael F Duffy, Stuart A Ralph, Malcolm J McConville, Leann Tilley, Simon A Cobbold

Cell Reports | CELL PRESS | Published : 2019

DOI: 10.1016/j.celrep.2019.10.095

University of Melbourne Researchers

Matthew Dixon Author Infectious Diseases

Jessica Bridgford Author Medical Biology (W.E.H.I.)

Stuart Ralph Author Biochemistry and Pharmacology

Malcolm McConville Author Biochemistry and Pharmacology

Lee Yeoh Author Microbiology and Immunology

Grants

Funding Acknowledgements

We thank the Mass Spectrometry and Proteomics facility, Bio21 Institute, for mass spectrometry support and the Biological Optical Microscopy Platform. We thank the Australian Red Cross service for blood donations. We thank Prof. Paul Horrocks, Keele University, for plasmid reagents and Dr. Tobias Spielmann and Dr. Jakob Birnbaum, Bernhard Nocht Institute for Tropical Medicine, for GFP-2xFKBP-K13<SUP>WT</SUP> parasites. Moreover, We appreciate the thoughtful discussions and input from Dr. Heather Painter and Dr. Natalie Spillman. This work was supported by the National Health & Medical Research Council of Australia (NHMRC) and the Australian Research Council (ARC).