Journal article

Immune capacity determines outcome following surgery or trauma: a systematic review and meta-analysis

Ruiyi Jia, Moran Zhou, Camilla SL Tuttle, Andrea B Maier

European Journal of Trauma and Emergency Surgery | SPRINGER HEIDELBERG | Published : 2019


PURPOSE: Immunological functions are altered following physical injury. The magnitude of the immunological response is dependent on the initial injury. However, variability in the immune response exists within and between patients where only some patients are at risk of developing complications such as systemic inflammatory response syndrome after injury. This systematic review and meta-analysis assessed whether lipopolysaccharide (LPS) induced cytokine production capacity of leucocytes can be used as a functional test to predict the risk of developing complications after injury. METHODS: Medline, Embase and Web of Science were systematically searched to identify articles that investigated t..

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Funding Acknowledgements

We would like to acknowledge the kind assistance of P. Condron, senior liaison librarian at the University of Melbourne, for his contribution in developing the search strategy. This review was funded by an unrestricted grant of the University of Melbourne received by Prof. Andrea B. Maier.