Immune capacity determines outcome following surgery or trauma: a systematic review and meta-analysis

Abstract

Purpose: Immunological functions are altered following physical injury. The magnitude of the immunological response is dependent on the initial injury. However, variability in the immune response exists within and between patients where only some patients are at risk of developing complications such as systemic inflammatory response syndrome after injury. This systematic review and meta-analysis assessed whether lipopolysaccharide (LPS) induced cytokine production capacity of leucocytes can be used as a functional test to predict the risk of developing complications after injury. Methods: Medline, Embase and Web of Science were systematically searched to identify articles that investigated t..