Journal article
Hybrid diamond/ carbon fiber microelectrodes enable multimodal electrical/chemical neural interfacing
Maryam A Hejazi, Wei Tong, Alastair Stacey, Artemio Soto-Breceda, Michael R Ibbotson, Molis Yunzab, Matias I Maturana, Ali Almasi, Young Jun Jung, Shi Sun, Hamish Meffin, Jian Fang, Melanie EM Stamp, Kumaravelu Ganesan, Kate Fox, Aaqil Rifai, Athavan Nadarajah, Samira Falahatdoost, Steven Prawer, Nicholas V Apollo Show all
Biomaterials | Elsevier | Published : 2020
Abstract
Implantable medical devices are now in regular use to treat or ameliorate medical conditions, including movement disorders, chronic pain, cardiac arrhythmias, and hearing or vision loss. Aside from offering alternatives to pharmaceuticals, one major advantage of device therapy is the potential to monitor treatment efficacy, disease progression, and perhaps begin to uncover elusive mechanisms of diseases pathology. In an ideal system, neural stimulation, neural recording, and electrochemical sensing would be conducted by the same electrode in the same anatomical region. Carbon fiber (CF) microelectrodes are the appropriate size to achieve this goal and have shown excellent performance, in viv..
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Grants
Awarded by National Health and Medical Research Council of Australia
Awarded by Australian Research Council (ARC) through the ARC Centre of Excellence for Electromaterials Science
Awarded by NHMRC
Awarded by Australian Research Council
Funding Acknowledgements
This research was funded by a Project Grant from The National Health and Medical Research Council of Australia (GNT1101717). JF would like to thank the support from the Australian Research Council (ARC) through the ARC Centre of Excellence for Electromaterials Science (CE140100012). The authors acknowledge the use of the Advanced Microscopy Facility at Bio21 (The University of Melbourne) for SEM imaging and the National Vision Research Institute for use of electrophysiology equipment. The authors also acknowledge the facilities, and the scientific and technical assistance of the RMIT Microscopy & Microanalysis Facility (RMMF), a linked laboratory of Microscopy Australia. The work was performed in part at the Melbourne Centre for Nanofabrication (MCN) in the Victorian Node of the Australian National Fabrication Facility (ANFF). DJG is supported by NHMRC Project Grant GNT1101717 and by an ANFF/MCN Technology Ambassador Fellowship. MM is supported by the Melbourne Neuroscience Institute Fellowship. AN is supported by the Australian Research Council, through Linkage Grant LP160101515. We acknowledge the support of ANSTO, the Australian Synchrotron. SP is a shareholder of iBIONICS, a company developing a diamond based retinal implant. SP, MM, DJG, and NVA are shareholders and public officers of Carbon Cybernetics Pty Ltd, a company developing diamond and carbon-based medical device components. The other authors declare no conflict of interest.