Serum IgA Fc effector functions in infectious disease and cancer
Samantha K Davis, Kevin J Selva, Stephen J Kent, Amy W Chung
IMMUNOLOGY AND CELL BIOLOGY | WILEY | Published : 2020
Immunoglobulin (Ig) A is the most abundant antibody isotype present at mucosal surfaces and the second most abundant in human serum. In addition to preventing pathogen entry at mucosal surfaces, IgA can control and eradicate bacterial and viral infections through a variety of antibody-mediated innate effector cell mechanisms. The role of mucosal IgA in infection (e.g. neutralization) and in inflammatory homeostasis (e.g. allergy and autoimmunity) has been extensively investigated; by contrast, serum IgA is comparatively understudied. IgA binding to fragment crystallizable alpha receptor plays a dual role in the activation and inhibition of innate effector cell functions. Mounting evidence su..View full abstract
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Awarded by Australian NHMRC
Awarded by American Foundation for AIDS (amfAR)
This work was supported by an Australian NHMRC project grant (APP1125164) and American Foundation for AIDS (amfAR) Mathilde Krim Fellowship (#109882).