Journal article

Low tidal volume ventilation during anaesthesia for major surgery: protocol and statistical analysis plan

Dharshi Karalapillai, Laurence Weinberg, Phil Peyton, Louise Ellard, Raymond Hu, Brett Pearce, Chong Tan, David Story, Mark ODonnell, Patrick Hamilton, Chad Oughton, Jonathan Galtieri, Anthony Wilson, Ary Serpa Neto, Glenn Eastwood, Rinaldo Bellomo, Daryl A Jones

Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine | AUSTRALASIAN MED PUBL CO LTD | Published : 2019

Abstract

BACKGROUND: Mechanical ventilation is mandatory in patients undergoing general anaesthesia for major surgery. Tidal volumes higher than 10 mL/kg of predicted body weight have been advocated for intraoperative ventilation, but recent evidence suggests that low tidal volumes may benefit surgical patients. To date, the impact of low tidal volume compared with conventional tidal volume during surgery has only been assessed in clinical trials that also combine different levels of positive end-expiratory pressure (PEEP) in each arm. We aimed to assess the impact of low tidal volume compared with conventional tidal volume during general anaesthesia for surgery on the incidence of postoperative resp..

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