Journal article

Physical Activity as a Predictor of Clinical Trial Outcomes in Bipolar Depression: A Subanalysis of a Mitochondrial-Enhancing Nutraceutical Randomized Controlled Trial

Melanie M Ashton, Mohammadreza Mohebbi, Alyna Turner, Wolfgang Marx, Michael Berk, Gin S Malhi, Chee H Ng, Sue M Cotton, Seetal Dodd, Jerome Sarris, Malcolm Hopwood, Brendon Stubbs, Olivia M Dean

The Canadian Journal of Psychiatry | SAGE PUBLICATIONS INC | Published : 2019


OBJECTIVES: Individuals with bipolar disorder (BD) generally engage in low levels of physical activity (PA), and yet few studies have investigated the relationship between PA and change in BD symptom severity. The aim of this subanalysis of an adjunctive nutraceutical randomized controlled trial for the treatment of bipolar depression was to explore the relationship between PA, the active adjunctive treatments (a nutraceutical "mitochondrial cocktail"), and clinical outcomes. METHODS: Participants with bipolar depression were randomized to receive N-acetylcysteine alone, N-acetylcysteine with a combination of nutraceuticals (chosen for the potential to increase mitochondrial activity), or pl..

View full abstract


Awarded by NHMRC

Awarded by National Health and Medical Research Council (NHMRC)

Awarded by Health Education England (HEE)

Awarded by National Institute for Health Research (NIHR)

Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The study has been funded by CRC for Mental Health, the Stanley Medical Research Institute, and an NHMRC Project Grant (APP1026307). M.M.A. is supported by Deakin University, Australasian Society for Bipolar and Depressive Disorders (ASBDD)/Lundbeck, and Australian Rotary Health/Ian Parker Bipolar Research Fund. M.B. is supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (APP1059660 and APP1156072). S.C. is supported by a NHMRC Senior Research Fellowship (APP1136344). J.S. is funded by an NHMRC Clinical Research Fellowship (APP1125000). W.M. is supported by Deakin postdoctoral fellowship. B.S. is supported by a Clinical Lectureship (ICA-CL-2017-03-001) jointly funded by Health Education England (HEE) and the National Institute for Health Research (NIHR). B.S. is part funded by the NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust. This paper presents independent research supported by the National Institute for Health Research (NIHR) and the views expressed are those of the author(s) and not necessarily those of the (partner organisation), the NHS, the NIHR or the Department of Health and Social Care. O.M.D. is supported by a NHMRC R.D. Wright Biomedical Research Fellowship (APP1145634).