Journal article
IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis
MSY Low, EJ Brodie, PL Fedele, Y Liao, G Grigoriadis, A Strasser, A Kallies, SN Willis, J Tellier, W Shi, S Gabriel, K O'Donnell, C Pitt, SL Nutt, D Tarlinton
Cell Reports | CELL PRESS | Published : 2019
Abstract
Plasma cells can provide lifelong immunity by the continued production of high-affinity, antigen-specific antibody. Low et al. reveal that the transcription factor IRF4 acts within established plasma cells to prevent apoptosis and maintain cellular identity and mitochondrial homeostasis.
Grants
Awarded by Royal College of Pathologists of Australasia
Funding Acknowledgements
We acknowledge the help of the Walter and Eliza Hall Institute and AMREP Flow Cytometry Core Facilities and animal care facilities. This work was supported by the National Health and Medical Research Council (NHMRC, Australia) through program grant 1054925 and fellowships to A.S., A.K., S.L.N., and D.T. M.S.Y.L. was supported by a CRB Blackburn scholarship jointly from the NHMRC and the Royal Australasian College of Physicians; P.L.F. was supported by a Leukaemia Foundation of Australia Clinical Scholarship and a Royal College of Pathologists of Australasia Foundation Postgraduate Research Fellowship; S.N.W. was supported by the Walter and Eliza Hall Trust Centenary Fellowship; and W.S. was supported by a Walter and Eliza Hall Trust Centenary Fellowship sponsored by Commonwealth Serum Laboratories Limited.