Journal article

Lifetime Risk Factors for Pre- and Post-Bronchodilator Lung Function Decline A Population-based Study

Dinh S Bui, Jennifer L Perret, E Haydn Walters, Michael J Abramson, John A Burgess, Minh Q Bui, Gayan Bowatte, Adrian J Lowe, Melissa A Russell, Sheikh M Alif, Bruce R Thompson, Garun S Hamilton, Graham G Giles, Paul S Thomas, Stephen Morrison, David P Johns, Luke D Knibbs, Jan-Paul Zock, Alessandro Marcon, Judith Garcia-Aymerich Show all



Rationale: Interactions between early life and adult insults on lung function decline are not well understood, with most studies investigating prebronchodilator (pre-BD) FEV1 decline.Objectives: To investigate relationships between adult risk factors and pre- and post-BD lung function decline and their potential effect modification by early life and genetic factors.Methods: Multiple regression was used to examine associations between adult exposures (asthma, smoking, occupational exposures, traffic pollution, and obesity) and decline in both pre- and post-BD spirometry (forced expiratory volume in 1 s [FEV1], forced vital capacity [FVC], and FEV1/FVC) between ages 45 and 53 years in the Tasm..

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Funding Acknowledgements

The authors thank the TAHS study participants and previous investigators. They also thank Professor Mark Jenkins, Ph.D., Centre for Epidemiology and Biostatistics, The University of Melbourne, Victoria, a TAHS investigator, but not a co-author of this manuscript, for his assistance with obtaining funds and data collection. We also acknowledge all the respiratory scientists who collected data in the lung function laboratories of Tasmania, Victoria, Queensland, and New South Wales, and the research interviewers, data entry operators, and research officers. Finally, we thank the Archives Office of Tasmania for providing data from the 1968 TAHS questionnaires.