Posttreatment Intervention With Lycium Barbarum Polysaccharides is Neuroprotective in a Rat Model of Chronic Ocular Hypertension
Yamunadevi Lakshmanan, Francisca Siu Yin Wong, Bing Zuo, Kwok-Fai So, Viet Bui Bang, Henry Ho-Lung Chan
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2019
Purpose: To investigate the neuroprotective effects of Lycium barbarum polysaccharides (LBP) against chronic ocular hypertension (OHT) in rats and to consider if effects differed when treatment was applied before (pretreatment) or during (posttreatment) chronic IOP elevation. Methods: Sprague-Dawley rats (10-weeks old) underwent suture implantation around the limbus for 15 weeks (OHT) or 1 day (sham). Four experimental groups were studied, three OHT groups (n = 8 each) treated either with vehicle (PBS), LBP pretreatment or posttreatment, and a sham control (n = 5) received no treatment. LBP (1 mg/kg) pre- and posttreatment were commenced at 1 week before and 4 weeks after OHT induction, resp..View full abstract
Awarded by Research Grants Council, Hong Kong SAR
Awarded by Innovation and Technology Commission (ITC), Hong Kong SAR
Awarded by Hong Kong Polytechnic University, Hong Kong, SAR
Supported by grants from the General Research Fund (PolyU 151001/17M) from Research Grants Council, Hong Kong SAR, the Innovation and Technology Fund (P0012902) from the Innovation and Technology Commission (ITC), Hong Kong SAR, Central Research Grant (for Research Student), and Internal Research Grants (Z0GF) from The Hong Kong Polytechnic University, Hong Kong, SAR.