Modular platforms for the assembly of self-adjuvanting lipopeptide-based vaccines for use in an out-bred population
Weiguang Zeng, Kylie J Horrocks, Amabel CL Tan, Chinn Yi Wong, Brendon Y Chua, David C Jackson
Vaccine | ELSEVIER SCI LTD | Published : 2020
To facilitate the preparation of synthetic epitope-based self-adjuvanting vaccines capable of eliciting antibody responses in an out-bred population, we have developed two modular approaches. In the first, the Toll-like receptor 2 agonist Pam2Cys and the target antibody epitope are assembled as a module which is then coupled to a carrier protein as a source of antigens to stimulate T cell help. A vaccine candidate made in this way was shown to induce a specific immune response in four different strains of mice without the need for extraneous adjuvant. In the second approach, three vaccine components in the form of a target antibody epitope, a T helper cell epitope and Pam2Cys, were prepared ..View full abstract
Awarded by National Health and Medical Research Council of Australia
This work was supported by Program Grant 567122 from the National Health and Medical Research Council of Australia.