Journal article
Glucose and counterregulatory responses to exercise in adults with type 1 diabetes and impaired awareness of hypoglycemia using closed-loop insulin delivery: A randomized crossover study
MH Lee, S Vogrin, B Paldus, D Jayawardene, HM Jones, SA McAuley, V Obeyesekere, J Gooley, A La Gerche, RJ MacIsaac, V Sundararajan, AJ Jenkins, GM Ward, DN O'Neal
Diabetes Care | AMER DIABETES ASSOC | Published : 2020
DOI: 10.2337/dc19-1433
Abstract
OBJECTIVE: To evaluate exercise-related glucose and counterregulatory responses (CRR) in adults with type 1 diabetes with impaired awareness of hypoglycemia (IAH) using hybrid closed-loop (HCL) insulin delivery to maintain glucose homeostasis. RESEARCH DESIGN AND METHODS: Twelve participants undertook 45-min high-intensity intermittent exercise (HIIE) and moderate-intensity exercise (MIE) in random order. The primary outcome was continuous glucose monitoring (CGM) time in range (70-180 mg/dL) for 24-h post-exercise commencement. RESULTS: CGM time in range was similar for HIIE and MIE (median 79.5% [interquartile range 73.2, 87.6] vs. 76.1% [70.3, 83.9], P = 0.37), and time with levels <54mg/..
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Funding Acknowledgements
This investigator-initiated study was funded by a Diabetes Australia Research Program grant (Diabetes Australia Research Trust) and a St Vincent's Hospital Melbourne Research Endowment Fund grant. Material support was provided from Medtronic. M.H.L. is supported by a National Health and Medical Research Council (NHMRC) postgraduate scholarship, cofunded by Diabetes Australia. B.P. is supported by a University of Melbourne scholarship and research support from JDRF. S.A.M. is supported by a JDRF Early Career Diabetes Research Award. A.J.J. is supported by a NHMRC Practitioner Grant and is a Sydney Medical School Foundation Fellow.