Glucose and Counterregulatory Responses to Exercise in Adults With Type 1 Diabetes and Impaired Awareness of Hypoglycemia Using Closed-Loop Insulin Delivery: A Randomized Crossover Study
Melissa H Lee, Sara Vogrin, Barbora Paldus, Dilshani Jayawardene, Hannah M Jones, Sybil A McAuley, Varuni Obeyesekere, Judith Gooley, Andre La Gerche, Richard J MacIsaac, Vijaya Sundararajan, Alicia J Jenkins, Glenn M Ward, David N O'Neal
Diabetes Care | AMER DIABETES ASSOC | Published : 2020
OBJECTIVE: To evaluate exercise-related glucose and counterregulatory responses (CRR) in adults with type 1 diabetes with impaired awareness of hypoglycemia (IAH) using hybrid closed-loop (HCL) insulin delivery to maintain glucose homeostasis. RESEARCH DESIGN AND METHODS: Twelve participants undertook 45-min high-intensity intermittent exercise (HIIE) and moderate-intensity exercise (MIE) in random order. The primary outcome was continuous glucose monitoring (CGM) time in range (70-180 mg/dL) for 24-h postexercise commencement. RESULTS: CGM time in range was similar for HIIE and MIE (79.5% [73.2, 87.6] vs. 76.1% [70.3, 83.9], P = 0.37), and time with levels <54mg/dL postexercise commencement..View full abstract
This investigator-initiated study was funded by a Diabetes Australia Research Program grant (Diabetes Australia Research Trust) and a St Vincent's Hospital Melbourne Research Endowment Fund grant. Material support was provided from Medtronic. M.H.L. is supported by a National Health and Medical Research Council (NHMRC) postgraduate scholarship, cofunded by Diabetes Australia. B.P. is supported by a University of Melbourne scholarship and research support from JDRF. S.A.M. is supported by a JDRF Early Career Diabetes Research Award. A.J.J. is supported by a NHMRC Practitioner Grant and is a Sydney Medical School Foundation Fellow.