Journal article
Longitudinal degradation of the default/salience network axis in symptomatic individuals with elevated amyloid burden.
AP Schultz, RF Buckley, OL Hampton, MR Scott, MJ Properzi, C Peña-Gómez, JJ Pruzin, HS Yang, KA Johnson, RA Sperling, JP Chhatwal
Neuroimage Clinical | ELSEVIER SCI LTD | Published : 2020
Abstract
Resting-state functional connectivity MRI (rs-fcMRI) is a non-invasive imaging technique that has come into increasing use to understand disrupted neural network function in neuropsychiatric disease. However, despite extensive study over the past 15 years, the development of rs-fcMRI as a biomarker has been impeded by a lack of reliable longitudinal rs-fcMRI measures. Here we focus on longitudinal change along the Alzheimer's disease (AD) trajectory and demonstrate the utility of Template Based Rotation (TBR) in detecting differential longitudinal rs-fcMRI change between higher and lower amyloid burden individuals with mildly impaired cognition. Specifically, we examine a small (N = 24), but..
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Awarded by National Institutes of Health
Funding Acknowledgements
This research was supported grant funding from the National Institute on Aging at the National Institute of Health (NIA-NIH) primarily via R01AG027435, and in addition to the Harvard Aging Brain Study (P01AG036694), as well as R21AG060221, K23AG049087, K99AG061238, and K24AG035007. This research was carried out at the Athinoula A. Martinos Center for Biomedical Imaging at the Massachusetts General Hospital, using resources provided by the Center for Functional Neuroimaging Technologies [P41EB015896], a P41 Biotechnology Resource Grant supported by the National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health. This work also involved the use of instrumentation supported by the NIH Shared Instrumentation Grant Program and/or High-End Instrumentation Grant Program; specifically S10RR021110, S10RR023401, S10RR019307, S10RR019254, and S10RR023043.