Journal article

Migration and Differentiation of Neural Stem Cells Diverted From the Subventricular Zone by an Injectable Self-Assembling beta-Peptide Hydrogel

Sepideh Motamed, Mark P Del Borgo, Kun Zhou, Ketav Kulkarni, Peter J Crack, Tobias D Merson, Marie-Isabel Aguilar, David Finkelstein, John S Forsythe



Neural stem cells, which are confined in localised niches are unable to repair large brain lesions because of an inability to migrate long distances and engraft. To overcome these problems, previous research has demonstrated the use of biomaterial implants to redirect increased numbers of endogenous neural stem cell populations. However, the fate of the diverted neural stem cells and their progeny remains unknown. Here we show that neural stem cells originating from the subventricular zone can migrate to the cortex with the aid of a long-lasting injectable hydrogel within a mouse brain. Specifically, large numbers of neuroblasts were diverted to the cortex through a self-assembling β-peptide..

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Awarded by National Health and Medical Research Council

Awarded by Australian Research Council

Funding Acknowledgements

The Florey Institute of Neuroscience and Mental Health acknowledge the strong support from the Victorian Government and in particular funding from the Operational Infrastructure Support Grant. We gratefully acknowledge the support of the Melbourne Neuroscience Institute Interdisciplinary Seed Funding Scheme and National Health and Medical Research Council Project Grant (APP1156744 to PC, JF, M-IA, and DF). PC and TM are recipients of Australian Research Council Future Fellowships, FT110100218 and FT150100207, respectively.