Journal article

Alcohol consumption is associated with widespread changes in blood DNA methylation: Analysis of cross-sectional and longitudinal data

Pierre-Antoine Dugue, Rory Wilson, Benjamin Lehne, Harindra Jayasekara, Xiaochuan Wang, Chol-Hee Jung, JiHoon E Joo, Enes Makalic, Daniel F Schmidt, Laura Baglietto, Gianluca Severi, Christian Gieger, Karl-Heinz Ladwig, Annette Peters, Jaspal S Kooner, Melissa C Southey, Dallas R English, Melanie Waldenberger, John C Chambers, Graham G Giles Show all

ADDICTION BIOLOGY | WILEY | Published : 2019

Abstract

DNA methylation may be one of the mechanisms by which alcohol consumption is associated with the risk of disease. We conducted a large-scale, cross-sectional, genome-wide DNA methylation association study of alcohol consumption and a longitudinal analysis of repeated measurements taken several years apart. Using the Illumina HumanMethylation450 BeadChip, DNA methylation was measured in blood samples from 5606 Melbourne Collaborative Cohort Study (MCCS) participants. For 1088 of them, these measures were repeated using blood samples collected a median of 11 years later. Associations between alcohol intake and blood DNA methylation were assessed using linear mixed-effects regression models. In..

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Grants

Awarded by British Heart Foundation


Awarded by H2020 programs (iHealth-T2D)


Awarded by European Union FP7


Awarded by NIHR Official Development Assistance


Awarded by NIHR


Awarded by Wellcome Trust


Awarded by Medical Research Council


Awarded by European Foundation for Alcohol Research


Awarded by NHMRC


Awarded by Australian NHMRC


Funding Acknowledgements

British Heart Foundation, Grant/Award Number: SP/04/002; Bundesministerium fur Bildung und Forschung; ERAB: The European Foundation for Alcohol Research; National Health and Medical Research Council; National Institute for Health Research; Wellcome Trust; Singapore Translational Research Investigator; Singapore Ministry of Health's National Medical Research Council; H2020 programs, Grant/Award Number: iHealth-T2D, 643774; European Union FP7, Grant/Award Number: 279143; NIHR Official Development Assistance, Grant/Award Number: 16/136/68; NIHR, Grant/Award Number: RP-PG-0407-10371; Wellcome Trust, Grant/Award Numbers: 098381, 090532 and 084723/Z/08/Z; Medical Research Council, Grant/Award Numbers: G0700931 and G0601966; National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centre Imperial College Healthcare NHS Trust; European Foundation for Alcohol Research, Grant/Award Numbers: EA1817 and ERAB 2018; NHMRC, Grant/Award Numbers: 1061177, 1074383, 1043616, 1050198, 1027505, 1026892 and 1011618; Australian NHMRC, Grant/Award Numbers: 504711, 251553 and 209057; Australian National Health and Medical Research Council (NHMRC)