Alcohol consumption is associated with widespread changes in blood DNA methylation: Analysis of cross-sectional and longitudinal data

Pierre-Antoine Dugue; Rory Wilson; Benjamin Lehne; Harindra Jayasekara; Xiaochuan Wang; Chol-Hee Jung; JiHoon E Joo; Enes Makalic; Daniel F Schmidt; Laura Baglietto; Gianluca Severi; Christian Gieger; Karl-Heinz Ladwig; Annette Peters; Jaspal S Kooner; Melissa C Southey; Dallas R English; Melanie Waldenberger; John C Chambers; Graham G Giles; Roger L Milne

Journal article

Alcohol consumption is associated with widespread changes in blood DNA methylation: Analysis of cross-sectional and longitudinal data

Pierre-Antoine Dugue, Rory Wilson, Benjamin Lehne, Harindra Jayasekara, Xiaochuan Wang, Chol-Hee Jung, JiHoon E Joo, Enes Makalic, Daniel F Schmidt, Laura Baglietto, Gianluca Severi, Christian Gieger, Karl-Heinz Ladwig, Annette Peters, Jaspal S Kooner, Melissa C Southey, Dallas R English, Melanie Waldenberger, John C Chambers, Graham G Giles Show all

ADDICTION BIOLOGY | WILEY | Published : 2019

DOI: 10.1111/adb.12855

Download PDF

Abstract

DNA methylation may be one of the mechanisms by which alcohol consumption is associated with the risk of disease. We conducted a large-scale, cross-sectional, genome-wide DNA methylation association study of alcohol consumption and a longitudinal analysis of repeated measurements taken several years apart. Using the Illumina HumanMethylation450 BeadChip, DNA methylation was measured in blood samples from 5606 Melbourne Collaborative Cohort Study (MCCS) participants. For 1088 of them, these measures were repeated using blood samples collected a median of 11 years later. Associations between alcohol intake and blood DNA methylation were assessed using linear mixed-effects regression models. In..

View full abstract

University of Melbourne Researchers

Chol-Hee Jung Author Medicine, Dentistry and Health Sciences

Dallas English Author Melbourne School of Population and Global Health

Eric Ji-Hoon Joo Author Clinical Pathology

Enes Makalic Author Melbourne School of Population and Global Health

Gianluca Severi Author Melbourne School of Population and Global Health

Related Projects (2)

Epidemiology of chronic disease, health interventions and DNA studies

nan

Methylation of DNA and colorectal cancer

Methylation of DNA involves a change to the chemical composition of DNA. It can affect the function of genes and normal methylation is essen..

Grants

Awarded by British Heart Foundation

Awarded by H2020 programs (iHealth-T2D)

Awarded by European Union FP7

Awarded by NIHR Official Development Assistance

Awarded by NIHR

Awarded by Wellcome Trust

Awarded by Medical Research Council

Awarded by European Foundation for Alcohol Research

Awarded by NHMRC

Awarded by Australian NHMRC

Funding Acknowledgements

British Heart Foundation, Grant/Award Number: SP/04/002; Bundesministerium fur Bildung und Forschung; ERAB: The European Foundation for Alcohol Research; National Health and Medical Research Council; National Institute for Health Research; Wellcome Trust; Singapore Translational Research Investigator; Singapore Ministry of Health's National Medical Research Council; H2020 programs, Grant/Award Number: iHealth-T2D, 643774; European Union FP7, Grant/Award Number: 279143; NIHR Official Development Assistance, Grant/Award Number: 16/136/68; NIHR, Grant/Award Number: RP-PG-0407-10371; Wellcome Trust, Grant/Award Numbers: 098381, 090532 and 084723/Z/08/Z; Medical Research Council, Grant/Award Numbers: G0700931 and G0601966; National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centre Imperial College Healthcare NHS Trust; European Foundation for Alcohol Research, Grant/Award Numbers: EA1817 and ERAB 2018; NHMRC, Grant/Award Numbers: 1061177, 1074383, 1043616, 1050198, 1027505, 1026892 and 1011618; Australian NHMRC, Grant/Award Numbers: 504711, 251553 and 209057; Australian National Health and Medical Research Council (NHMRC)