The effect of increasing dialysate magnesium on calciprotein particles, inflammation and bone markers: post hoc analysis from a randomized controlled clinical trial
Iain Bressendorff, Ditte Hansen, Andreas Pasch, Stephen G Holt, Morten Schou, Lisbet Brandi, Edward R Smith
NEPHROLOGY DIALYSIS TRANSPLANTATION | OXFORD UNIV PRESS | Published : 2021
BACKGROUND: The formation of calciprotein particles (CPPs) may be an important component of the humoral defences against ectopic calcification. Although magnesium (Mg) has been shown to delay the transition of amorphous calcium-/phosphate-containing primary CPP (CPP-1) to crystalline apatite-containing secondary CPP (CPP-2) ex vivo, effects on the endogenous CPP pool are unknown. METHODS: We used post hoc analyses from a randomized double-blind parallel-group controlled clinical trial of 28 days treatment with high dialysate Mg of 2.0 mEq/L versus standard dialysate Mg of 1.0 mEq/L in 57 subjects undergoing maintenance hemodialysis for end-stage kidney disease. CPP load, markers of systemic ..View full abstract
This work was partly supported by the Royal Melbourne Hospital Home Lottery Project Grant to S.G.H. and E.R.S.