Journal article

Higher frequency of vertebrate-infecting viruses in the gut of infants born to mothers with type 1 diabetes

Ki Wook Kim, Digby W Allen, Thomas Briese, Jennifer J Couper, Simon C Barry, Peter G Colman, Andrew M Cotterill, Elizabeth A Davis, Lynne C Giles, Leonard C Harrison, Mark Harris, Aveni Haynes, Jessica L Horton, Sonia R Isaacs, Komal Jain, Walter I Lipkin, Kelly McGorm, Grant Morahan, Claire Morbey, Ignatius CN Pang Show all

Pediatric Diabetes | WILEY | Published : 2020

Abstract

Background: Microbial exposures in utero and early life shape the infant microbiome, which can profoundly impact on health. Compared to the bacterial microbiome, very little is known about the virome. We set out to characterize longitudinal changes in the gut virome of healthy infants born to mothers with or without type 1 diabetes using comprehensive virome capture sequencing. Methods: Healthy infants were selected from Environmental Determinants of Islet Autoimmunity (ENDIA), a prospective cohort of Australian children with a first‐degree relative with type 1 diabetes, followed from pregnancy. Fecal specimens were collected three‐monthly in the first year of life. Results: Among 25 infants..

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Grants

Awarded by Juvenile Diabetes Research Foundation Australia


Awarded by Juvenile Diabetes Research Foundation International


Awarded by National Health and Medical Research Council


Awarded by National Institutes of Health


Funding Acknowledgements

Juvenile Diabetes Research Foundation Australia, Grant/Award Number: 4-SRA-2015-127-M-B; Juvenile Diabetes Research Foundation International, Grant/Award Number: 3-SRA-2017-417-A-N; Leona M. and Harry B. Helmsley Charitable Trust; National Health and Medical Research Council, Grant/Award Numbers: APP1044694, APP1045777, APP1078106; National Institutes of Health, Grant/Award Number: U19 AI10976