Journal article
Higher frequency of vertebrate-infecting viruses in the gut of infants born to mothers with type 1 diabetes
Ki Wook Kim, Digby W Allen, Thomas Briese, Jennifer J Couper, Simon C Barry, Peter G Colman, Andrew M Cotterill, Elizabeth A Davis, Lynne C Giles, Leonard C Harrison, Mark Harris, Aveni Haynes, Jessica L Horton, Sonia R Isaacs, Komal Jain, Walter I Lipkin, Kelly McGorm, Grant Morahan, Claire Morbey, Ignatius CN Pang Show all
PEDIATRIC DIABETES | WILEY | Published : 2020
DOI: 10.1111/pedi.12952
Abstract
Background: Microbial exposures in utero and early life shape the infant microbiome, which can profoundly impact on health. Compared to the bacterial microbiome, very little is known about the virome. We set out to characterize longitudinal changes in the gut virome of healthy infants born to mothers with or without type 1 diabetes using comprehensive virome capture sequencing. Methods: Healthy infants were selected from Environmental Determinants of Islet Autoimmunity (ENDIA), a prospective cohort of Australian children with a first‐degree relative with type 1 diabetes, followed from pregnancy. Fecal specimens were collected three‐monthly in the first year of life. Results: Among 25 infants..
View full abstractGrants
Awarded by Juvenile Diabetes Research Foundation Australia
Awarded by Juvenile Diabetes Research Foundation International
Awarded by National Health and Medical Research Council
Awarded by National Institutes of Health
Funding Acknowledgements
Juvenile Diabetes Research Foundation Australia, Grant/Award Number: 4-SRA-2015-127-M-B; Juvenile Diabetes Research Foundation International, Grant/Award Number: 3-SRA-2017-417-A-N; Leona M. and Harry B. Helmsley Charitable Trust; National Health and Medical Research Council, Grant/Award Numbers: APP1044694, APP1045777, APP1078106; National Institutes of Health, Grant/Award Number: U19 AI10976