A TGF-β type II receptor that associates with developmental transition in Haemonchus contortus in vitro.
Li He, Robin B Gasser, Tingting Li, Wenda Di, Fangfang Li, Hongrun Zhang, Caixian Zhou, Rui Fang, Min Hu
PLoS Neglected Tropical Diseases | Public Library of Science | Published : 2019
BACKGROUND: The TGF-β signalling pathway plays a key role in regulating dauer formation in the free-living nematode Caenorhabditis elegans, and previous work has shown that TGF-β receptors are involved in parasitic nematodes. Here, we explored the structure and function of a TGF-β type II receptor homologue in the TGF-β signalling pathway in Haemonchus contortus, a highly pathogenic, haematophagous parasitic nematode. METHODOLOGY/PRINCIPAL FINDINGS: Amino acid sequence and phylogenetic analyses revealed that the protein, called Hc-TGFBR2 (encoded by the gene Hc-tgfbr2), is a member of TGF-β type II receptor family and contains conserved functional domains, both in the extracellular region co..View full abstract
Awarded by National Key Basic Research Program (973 program) of China
Awarded by Fundamental Research Funds for the Central Universities
Awarded by Huazhong Agricultural University Scientific & Technological Self Innovation Foundation
Awarded by Natural Science Foundation of Hubei Province
This study was supported by the National Key Basic Research Program (973 program) of China (grant no. 2015CB150300) and the Fundamental Research Funds for the Central Universities (grant no. 2662017PY084) to M.H.; the Huazhong Agricultural University Scientific & Technological Self Innovation Foundation (Program no. 2015RC005), the Australian Research Council (ARC) and Yourgene Bioscience, Melbourne Water Corporation, the National Health and Medical Research Council (NHMRC) of Australiato R.B.G.; and the Natural Science Foundation of Hubei Province (Grant No. 2017CFA020) to M.H., R.F., Y.Z. and J.Z. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.