Journal article

Establishment of Wolbachia Strain wAlbB in Malaysian Populations of Aedes aegypti for Dengue Control

Wasi A Nazni, Ary A Hoffmann, Ahmad NoorAfizah, Yoon Ling Cheong, Maria V Mancini, Nicholas Golding, Ghazali MR Kamarul, Mohd AK Arif, Hasim Thohir, Halim NurSyamimi, M Zabari ZatilAqmar, Mazni NurRuqqayah, Amran NorSyazwani, Azmi Faiz, Francis-Rudin MN Irfan, Subramaniam Rubaaini, Nasir Nuradila, Nasir MN Nizam, Saidin M Irwan, Nancy M Endersby-Harshman Show all

CURRENT BIOLOGY | CELL PRESS | Published : 2019

Abstract

Dengue has enormous health impacts globally. A novel approach to decrease dengue incidence involves the introduction of Wolbachia endosymbionts that block dengue virus transmission into populations of the primary vector mosquito, Aedes aegypti. The wMel Wolbachia strain has previously been trialed in open releases of Ae. aegypti; however, the wAlbB strain has been shown to maintain higher density than wMel at high larval rearing temperatures. Releases of Ae. aegypti mosquitoes carrying wAlbB were carried out in 6 diverse sites in greater Kuala Lumpur, Malaysia, with high endemic dengue transmission. The strain was successfully established and maintained at very high population frequency at s..

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Grants

Awarded by Wellcome Trust


Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

The primary funding for the study was provided by Wellcome Trust Award 108508, with additional funding from Wellcome Trust Award 202888 and National Health and Medical Research Council of Australia Awards 1118640 and 1132412 and funding from Ministry of Health Malaysia. The authors thank the Director General of Health, Malaysia, for permission to publish. Thanks are also due to the Deputy Director General of Health (Research & Technical Support), Malaysia, and Director, Institute for Medical Research, Kuala Lumpur, for the support. We acknowledge Datuk Dr. Shahnaz Murad and Dr. Rose Nani Mudin for the support throughout the project.