Journal article

Clarifying the neural substrates of threat and safety reversal learning in humans

Hannah S Savage, Christopher G Davey, Miquel A Fullana, Ben J Harrison



Responding flexibly to sources of threat and safety is critical to the adaptive regulation of emotions, including fear. At a neural systems level, such flexibility is thought to rely on an extended neural circuitry involving the dorsal anterior cingulate cortex (dACC) and ventromedial prefrontal cortices (vmPFC), although precisely how this occurs remains unclear. Using a novel fear reversal task and functional magnetic resonance imaging (fMRI), we examined the neural correlates of threat and safety reversal learning and their associations with individual differences in anxious responding in a large sample of healthy adolescents and young adults. Overall, participants demonstrated successful..

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Awarded by National Health and Medical Research Council of Australia (NHMRC)

Awarded by NHMRC

Funding Acknowledgements

This study was supported by a National Health and Medical Research Council of Australia (NHMRC) Project Grant (1161897) to BJH, CGD and MAF. HSS was supported by an Australian Government Research Training Program (RTP) Scholarship. BJH was supported by a NHMRC Career Development Fellowship (1124472). CGD was supported by an NHMRC Career Development Fellowship (1061757). The authors thank Laura Finlayson-Short, Yara Toenders, Alec Jamieson and Lisa Incerti for their contributions to data collection, as well as staff from the Sunshine Hospital Medical Imaging Department (Western Health, Melbourne).