Journal article

HLA-E-restricted CD8( ) T Lymphocytes Efficiently Control Mycobacterium tuberculosis and HIV-1 Coinfection

Marco Pio La Manna, Valentina Orlando, Teresa Prezzemolo, Paola Di Carlo, Antonio Cascio, Giovanni Delogu, Guido Poli, Lucy C Sullivan, Andrew G Brooks, Francesco Dieli, Nadia Caccamo

American Journal of Respiratory Cell and Molecular Biology | AMER THORACIC SOC | Published : 2020

Abstract

We investigated the contribution of human leukocyte antigen A2 (HLA-A2) and HLA-E-restricted CD8+ T cells in patients with Mycobacterium tuberculosis and human immunodeficiency virus 1 (HIV-1) coinfection. HIV-1 downregulates HLA-A, -B, and -C molecules in infected cells, thus influencing recognition by HLA class I-restricted CD8+ T cells but not by HLA-E-restricted CD8+ T cells, owing to the inability of the virus to downmodulate their expression. Therefore, antigen-specific HLA-E-restricted CD8+ T cells could play a protective role in Mycobacterium tuberculosis and HIV-1 coinfection. HLA-E- and HLA-A2-restricted Mycobacterium tuberculosis-specific CD8+ T cells were tested in vitro for cyto..

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Grants

Awarded by European Commission within the Seventh Framework Program NEWTBVAC (New Generation Tuberculosis Vaccines)


Awarded by Horizon2020 Program TBVAC2020 (Tuberculosis Vaccine)


Awarded by EMI-TB (Eliciting Mucosal Immunity in Tuberculosis)


Funding Acknowledgements

Supported by grants from the European Commission within the Seventh Framework Program NEWTBVAC (New Generation Tuberculosis Vaccines) (contract no. HEALTH-F3-2009-241745), the Horizon2020 Program TBVAC2020 (Tuberculosis Vaccine) (contract no. 643381), and EMI-TB (Eliciting Mucosal Immunity in Tuberculosis) (contract no. 643558). The text represents the authors' views and does not necessarily represent the position of the European Commission, which will not be liable for the use made of such information.