Journal article
HLA-E-restricted CD8 T lymphocytes efficiently control mycobacterium tuberculosis and HIV-1 coinfection
MP La Manna, V Orlando, T Prezzemolo, P Di Carlo, A Cascio, G Delogu, G Poli, LC Sullivan, AG Brooks, F Dieli, N Caccamo
American Journal of Respiratory Cell and Molecular Biology | AMER THORACIC SOC | Published : 2020
Abstract
We investigated the contribution of human leukocyte antigen A2 (HLAA2) and HLA-E-restrictedCD8+ Tcells in patients withMycobacterium tuberculosis and human immunodeficiency virus 1 (HIV-1) coinfection. HIV-1 downregulatesHLA-A, -B, and -Cmolecules in infected cells, thus influencing recognition byHLAclass I-restrictedCD8+Tcells butnot by HLA-E-restricted CD8+ T cells, owing to the inability of the virus to downmodulate their expression. Therefore, antigen-specific HLAE- restricted CD8+ T cells could play a protective role in Mycobacterium tuberculosis and HIV-1 coinfection. HLA-E- and HLA-A2-restricted Mycobacterium tuberculosis-specific CD8+ T cells were tested in vitro for cytotoxic and mi..
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Awarded by European Commission
Funding Acknowledgements
Supported by grants from the European Commission within the Seventh Framework Program NEWTBVAC (New Generation Tuberculosis Vaccines) (contract no. HEALTH-F3-2009-241745), the Horizon2020 Program TBVAC2020 (Tuberculosis Vaccine) (contract no. 643381), and EMI-TB (Eliciting Mucosal Immunity in Tuberculosis) (contract no. 643558). The text represents the authors' views and does not necessarily represent the position of the European Commission, which will not be liable for the use made of such information.