Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon
Jesse J DiCello, Simona E Carbone, Ayame Saito, Pradeep Rajasekhar, Rhian A Ceredig, Vi Pham, Celine Valant, Arthur Christopoulos, Nicholas A Veldhuis, Meritxell Canals, Dominique Massotte, Daniel P Poole
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY | ELSEVIER INC | Published : 2020
BACKGROUND & AIMS: Functional interactions between the mu opioid receptor (MOR) and delta opioid receptor (DOR) represent a potential target for novel analgesics and may drive the effects of the clinically approved drug eluxadoline for the treatment of diarrhea-predominant irritable bowel syndrome. Although the enteric nervous system (ENS) is a likely site of action, the coexpression and potential interaction between MOR and DOR in the ENS are largely undefined. In the present study, we have characterized the distribution of MOR in the mouse ENS and examined MOR-DOR interactions by using pharmacologic and cell biology techniques. METHODS: MOR and DOR expression was defined by using MORmCherr..View full abstract
Awarded by NHMRC Australia
Awarded by Fondation pour la Recherche Medicale
NHMRC Australia 1049730 and 1121029 (D.P.P., M.C.), 1083480 (D.P.P.); NHMRC Australian Postgraduate Award (J.J.D.). D.M. was supported by CNRS and University of Strasbourg. R.A.C. was funded by the Ministere de l'Enseignement Superieur et de la Recherche and the Fondation pour la Recherche Medicale (DPA20140629804).