Journal article
Synthesis and structure−activity relationships of teixobactin
JA Karas, F Chen, EK Schneider-Futschik, Z Kang, M Hussein, J Swarbrick, D Hoyer, AM Giltrap, RJ Payne, J Li, T Velkov
Annals of the New York Academy of Sciences | WILEY | Published : 2020
DOI: 10.1111/nyas.14282
Abstract
The discovery of antibiotics has led to the effective treatment of bacterial infections that were otherwise fatal and has had a transformative effect on modern medicine. Teixobactin is an unusual depsipeptide natural product that was recently discovered from a previously unculturable soil bacterium and found to possess potent antibacterial activity against several Gram positive pathogens, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci. One of the key features of teixobactin as an antibiotic lead is that resistance could not be generated in a laboratory setting. This is proposed to be a result of a mechanism of action that involves binding to essent..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was funded by the Australian National Health and Medical Research Council (NHMRC, APP1128891). T.V. and J.L are also supported by a research grant from the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (R01AI111965). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases of the National Institutes of Health. J.L. is an Australian National Health and Medical Research Council (NHMRC) Principal Research Fellow, and T.V. is an Australian NHMRC Industry Career Development Level 2 Research Fellow. E.K.S.-F. is an Australian NHMRC Peter Doherty Research Fellow.