Levels of Human Immunodeficiency Virus DNA Are Determined Before ART Initiation and Linked to CD8 T-Cell Activation and Memory Expansion
Genevieve E Martin, Matthew Pace, Freya M Shearer, Eva Zilber, Jacob Hurst, Jodi Meyerowitz, John P Thornhill, Julianne Lwanga, Helen Brown, Nicola Robinson, Emily Hopkins, Natalia Olejniczak, Nneka Nwokolo, Julie Fox, Sarah Fidler, Christian B Willberg, John Frater
JOURNAL OF INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2020
Initiation of antiretroviral therapy (ART) in early compared with chronic human immunodeficiency virus (HIV) infection is associated with a smaller HIV reservoir. This longitudinal analysis of 60 individuals who began ART during primary HIV infection (PHI) investigates which pre- and posttherapy factors best predict HIV DNA levels (a correlate of reservoir size) after treatment initiation during PHI. The best predictor of HIV DNA at 1 year was pre-ART HIV DNA, which was in turn significantly associated with CD8 memory T-cell differentiation (effector memory, naive, and T-bet-Eomes- subsets), CD8 T-cell activation (CD38 expression) and T-cell immunoglobulin and mucin-domain containing-3 (Tim-..View full abstract
Awarded by Medical Research Council
This work was supported by the Medical Research Council (grant MR/L006588/1 to J. Frater) and the National Institute of Health Research Oxford Biomedical Research Centre.