Journal article
Levels of human immunodeficiency virus dna are determined before art initiation and linked to CD8 T-cell activation and memory expansion
GE Martin, M Pace, FM Shearer, E Zilber, J Hurst, J Meyerowitz, JP Thornhill, J Lwanga, H Brown, N Robinson, E Hopkins, N Olejniczak, N Nwokolo, J Fox, S Fidler, CB Willberg, J Frater
Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2020
Abstract
Initiation of antiretroviral therapy (ART) in early compared with chronic human immunodeficiency virus (HIV) infection is associated with a smaller HIV reservoir. This longitudinal analysis of 60 individuals who began ART during primary HIV infection (PHI) investigates which pre- and posttherapy factors best predict HIV DNA levels (a correlate of reservoir size) after treatment initiation during PHI. The best predictor of HIV DNA at 1 year was pre-ART HIV DNA, which was in turn significantly associated with CD8 memory T-cell differentiation (effector memory, naive, and T-bet-Eomes- subsets), CD8 T-cell activation (CD38 expression) and T-cell immunoglobulin and mucin-domain containing-3 (Tim-..
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Awarded by UK Research and Innovation
Funding Acknowledgements
This work was supported by the Medical Research Council (grant MR/L006588/1 to J. Frater) and the National Institute of Health Research Oxford Biomedical Research Centre.