Journal article
Cell death following the loss of ADAR1 mediated A-to-I RNA editing is not effected by the intrinsic apoptosis pathway
CR Walkley, BT Kile
Cell Death and Disease | NATURE PUBLISHING GROUP | Published : 2019
Open access
Abstract
Modifications of RNA, collectively termed as the epitranscriptome, are widespread, evolutionarily conserved and contribute to gene regulation and protein diversity in healthy and disease states. There are >160 RNA modifications described, greatly exceeding the number of modifications to DNA. Of these, adenosine-to-inosine (A-to-I) RNA editing is one of the most common. There are tens of thousands of A-to-I editing sites in mouse, and millions in humans. Upon translation or sequencing an inosine base is decoded as guanosine, leading to A-to-G mismatches between the RNA and DNA. Inosine has different base pairing properties to adenosine and as a result editing not only alters the RNA code but ..
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Awarded by Victorian Cancer Agency
Funding Acknowledgements
The authors thank A. Goradia and L. Johnson for technical assistance, and L. Purton and J. Heraud-Farlow for comments and discussion; WEHI Animal Facility staff for care of experimental animals; St. Vincent's Institute Flow Cytometry Core Facility. Due to citation number restrictions we have not been able to cite all relevant literature and apologize in advance to colleagues whose work has not been referenced. This work was supported by the National Health and Medical Research Council, Australia (C.R.W. and J.B. Li, APP1102006/APP1144049; B.T.K., Program Grant No. 1113577, Project Grant No. 1077750, Fellowship No. 1063008); Victorian Cancer Agency Research Fellowship (C.R.W.; MCRF15015); and in part by the Victorian State Government Operational Infrastructure Support (to St Vincent's Institute).