Journal article

Nrf2 controls iron homoeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin

Pei Jin Lim, Tiago L Duarte, Joao Arezes, Daniel Garcia-Santos, Amel Hamdi, Sant-Rayn Pasricha, Andrew E Armitage, Hema Mehta, Sarah Wideman, Ana G Santos, Andreia Santos-Goncalves, Alireza Morovat, Jim R Hughes, Elizabeth Soilleux, Chia-Yu Wang, Abraham L Bayer, Paul Klenerman, Christian B Willberg, Richard C Hartley, Michael P Murphy Show all

Nature Metabolism | NATURE RESEARCH | Published : 2019

Grants

Awarded by UK Medical Research Council (MRC Human Immunology Unit)


Awarded by Fundacao para a Ciencia e Tecnologia


Awarded by Norte 2020 Portugal Regional Operational Programme


Awarded by National Institutes of Health


Awarded by Medical Research Council UK


Awarded by Wellcome Trust


Awarded by Canadian Institutes of Health Research


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Funding Acknowledgements

The authors thank the staff of the University of Oxford Department of Biomedical Services for animal husbandry, M. Nairz (Medical University of Innsbruck) for assistance with flow cytometry and A. Townsend (Weatherall Institute of Molecular Medicine) for helpful advice and discussions. This work was supported by the UK Medical Research Council (MRC Human Immunology Unit core funding to H.D., award no. MC_UU_12010/10) and Radcliffe Department of Medicine (RDM Scholars Program to P.J.L.). The work conducted at the Instituto de Biologia Molecular e Celular was supported by FEDER funds through COMPETE and by Portuguese funds through Fundacao para a Ciencia e Tecnologia (grant nos. PTDC/BIM-MET/0739/2012 and SFRH/BPD/108207/2015 to T.L.D.), and the Norte 2020 Portugal Regional Operational Programme (grant no. Norte-01-0145-FEDER-000012). J.L.B. was supported by the National Institutes of Health (grant no. RO1-DK087727) and Massachusetts General Hospital (Howard Goodman Award). Work in M.P.M.'s lab is supported by the Medical Research Council UK (grant no. MC_U105663142) and by a Wellcome Trust Investigator award (no. 110159/Z/15/Z). A.M.H., D.G.S. and P.P. were funded by grants from the Canadian Institutes of Health Research (grant nos. MOP-14100 and MOP-126064).