Journal article

An Erg driven transcriptional program controls B-lymphopoiesis

Ashley Ng, Hannah Coughlan, Soroor Hediyeh-zadeh, Kira Behrens, Timothy Johanson, Michael Sze Yuan Low, Charles Bell, Omer Gilan, Yih-Chih Chan, Andrew Kueh, Thomas Boudier, Ladina DiRago, Craig Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark Dawson, Rhys Allan, Marco Herold Show all

Published : 2019

Abstract

Summary/Abstract B-cell development is initiated by the stepwise differentiation of hematopoietic stem cells into lineage committed progenitors, ultimately generating the mature B-cells that mediate protective immunity. This highly regulated process also generates clonal immunological diversity via recombination of immunoglobulin genes. While several transcription factors that control B-cell development and V(D)J recombination have been defined, how these processes are initiated and coordinated into a precise regulatory network remains poorly understood. Here, we show that the transcription factor ETS Related Gene ( Erg ) is essential for the earliest steps in B-cell differentiation. Erg ini..

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