Correction and Control of Hyperammonemia in Acute Liver Failure: The Impact of Continuous Renal Replacement Timing, Intensity, and Duration

Abstract

OBJECTIVES: Hyperammonemia is a key contributing factor for cerebral edema in acute liver failure. Continuous renal replacement therapy may help reduce ammonia levels. However, the optimal timing, mode, intensity, and duration of continuous renal replacement therapy in this setting are unknown. We aimed to study continuous renal replacement therapy use in acute liver failure patients and to assess its impact on hyperammonemia. DESIGN: Retrospective observational study. SETTING: ICU within a specialized liver transplant hospital. PATIENTS: Fifty-four patients with acute liver failure. INTERVENTIONS: Data were obtained from medical records and analyzed for patient characteristics, continuous r..